Structure of Escherichia coli aspartate α-decarboxylase Asn72Ala: probing the role of Asn72 in pyruvoyl cofactor formation

The crystal structure of the Asn72Ala site-directed mutant of Escherichia coli aspartate α-decarboxylase (ADC) has been determined at 1.7 Å resolution. The refined structure is consistent with the presence of a hydrolysis product serine in the active site in place of the pyruvoyl group required for...

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Bibliographic Details
Main Authors: Webb, Michael E., Lobley, Carina M. C., Soliman, Fatima, Kilkenny, Mairi L., Smith, Alison G., Blundell, Tom L., Abell, Chris
Format: Artigo
Language:Inglês
Published: International Union of Crystallography 2012
Subjects:
Structural Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3325809/
https://ncbi.nlm.nih.gov/pubmed/22505409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309112009487
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