Structural basis for lack of toxicity of the diphtheria toxin mutant CRM197

CRM197 is an enzymatically inactive and nontoxic form of diphtheria toxin that contains a single amino acid substitution (G52E). Being naturally nontoxic, CRM197 is an ideal carrier protein for conjugate vaccines against encapsulated bacteria and is currently used to vaccinate children globally agai...

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Detalhes bibliográficos
Main Authors: Malito, Enrico, Bursulaya, Badry, Chen, Connie, Surdo, Paola Lo, Picchianti, Monica, Balducci, Enrico, Biancucci, Marco, Brock, Ansgar, Berti, Francesco, Bottomley, Matthew James, Nissum, Mikkel, Costantino, Paolo, Rappuoli, Rino, Spraggon, Glen
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3325714/
https://ncbi.nlm.nih.gov/pubmed/22431623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1201964109
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