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Direct observation of multiple misfolding pathways in a single prion protein molecule
Protein misfolding is a ubiquitous phenomenon associated with a wide range of diseases. Single-molecule approaches offer a powerful tool for deciphering the mechanisms of misfolding by measuring the conformational fluctuations of a protein with high sensitivity. We applied single-molecule force spec...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3325692/ https://ncbi.nlm.nih.gov/pubmed/22421432 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1107736109 |
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