Non-Agonistic Bivalent Antibodies That Promote c-MET Degradation and Inhibit Tumor Growth and Others Specific for Tumor Related c-MET

The c-MET receptor has a function in many human cancers and is a proven therapeutic target. Generating antagonistic or therapeutic monoclonal antibodies (mAbs) targeting c-MET has been difficult because bivalent, intact anti-Met antibodies frequently display agonistic activity, necessitating the use...

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Главные авторы: Greenall, Sameer A., Gherardi, Ermanno, Liu, Zhanqi, Donoghue, Jacqueline F., Vitali, Angela A., Li, Qian, Murphy, Roger, Iamele, Luisa, Scott, Andrew M., Johns, Terrance G.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2012
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3325269/
https://ncbi.nlm.nih.gov/pubmed/22511956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034658
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