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Mapping the Environmental Fitness Landscape of a Synthetic Gene Circuit

Gene expression actualizes the organismal phenotypes encoded within the genome in an environment-dependent manner. Among all encoded phenotypes, cell population growth rate (fitness) is perhaps the most important, since it determines how well-adapted a genotype is in various environments. Traditiona...

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Bibliografiske detaljer
Main Authors: Nevozhay, Dmitry, Adams, Rhys M., Van Itallie, Elizabeth, Bennett, Matthew R., Balázsi, Gábor
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3325171/
https://ncbi.nlm.nih.gov/pubmed/22511863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002480
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