Essential role for Stat5a/b in myeloproliferative neoplasms induced by BCR-ABL1 and JAK2(V617F) in mice

STAT5 proteins are constitutively activated in malignant cells from many patients with leukemia, including the myeloproliferative neoplasms (MPNs) chronic myeloid leukemia (CML) and polycythemia vera (PV), but whether STAT5 is essential for the pathogenesis of these diseases is not known. In the pre...

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Bibliographic Details
Main Authors: Walz, Christoph, Ahmed, Wesam, Lazarides, Katherine, Betancur, Monica, Patel, Nihal, Hennighausen, Lothar, Zaleskas, Virginia M., Van Etten, Richard A.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2012
Subjects:
Myeloid Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3325042/
https://ncbi.nlm.nih.gov/pubmed/22234689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-12-397554
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