Dual-Specificity Phosphatase CDC25A/B Inhibitor Identified from a Focused Library with Nonelectrophilic Core Structure

[Image: see text] Focused libraries of enamine derivatives with a nonacidic, nonelectrophilic core structure were screened for inhibitors of dual-specificity protein phosphatases, and an o-hydroxybenzyl derivative RE44 (10d) was identified as a selective inhibitor of CDC25A/B. This inhibitor induced...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Tsuchiya, Ayako, Hirai, Go, Koyama, Yusuke, Oonuma, Kana, Otani, Yuko, Osada, Hiroyuki, Sodeoka, Mikiko
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2012
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3324983/
https://ncbi.nlm.nih.gov/pubmed/22506091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml2002778
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker