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Replacing Conventional Carbon Nucleophiles with Electrophiles: Nickel-Catalyzed Reductive Alkylation of Aryl Bromides and Chlorides

[Image: see text] A general method is presented for the synthesis of alkylated arenes by the chemoselective combination of two electrophilic carbons. Under the optimized conditions, a variety of aryl and vinyl bromides are reductively coupled with alkyl bromides in high yields. Under similar conditi...

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Autors principals: Everson, Daniel A., Jones, Brittany A., Weix, Daniel J.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2012
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3324882/
https://ncbi.nlm.nih.gov/pubmed/22463689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja301769r
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