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Mechanism of N(10)-formyltetrahydrofolate synthetase derived from complexes with intermediates and inhibitors
N(10)-formyltetrahydrofolate synthetase (FTHFS) is a folate enzyme that catalyzes the formylation of tetrahydrofolate (THF) in an ATP dependent manner. Structures of FTHFS from the thermophilic homoacetogen, Moorella thermoacetica, complexed with (1) a catalytic intermediate—formylphosphate (XPO) an...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Wiley Subscription Services, Inc., A Wiley Company
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3324766/ https://ncbi.nlm.nih.gov/pubmed/22109967 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2005 |
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