Structural basis for extracellular interactions between calcitonin receptor-like receptor and receptor activity-modifying protein 2 for adrenomedullin-specific binding

The calcitonin receptor-like receptor (CRLR), a class B GPCR, forms a heterodimer with receptor activity-modifying protein 2 (RAMP2), and serves as the adrenomedullin (AM) receptor to control neovascularization, while CRLR and RAMP1 form the calcitonin gene-related peptide (CGRP) receptor. Here, we...

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Autors principals: Kusano, Seisuke, Kukimoto-Niino, Mutsuko, Hino, Nobumasa, Ohsawa, Noboru, Okuda, Ken-ichi, Sakamoto, Kensaku, Shirouzu, Mikako, Shindo, Takayuki, Yokoyama, Shigeyuki
Format: Artigo
Idioma:Inglês
Publicat: Wiley Subscription Services, Inc., A Wiley Company 2012
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3324764/
https://ncbi.nlm.nih.gov/pubmed/22102369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2003
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