Early Treatment with Fumagillin, an Inhibitor of Methionine Aminopeptidase-2, Prevents Pulmonary Hypertension in Monocrotaline-Injured Rats

Pulmonary Hypertension (PH) is a pathophysiologic condition characterized by hypoxemia and right ventricular strain. Proliferation of fibroblasts, smooth muscle cells, and endothelial cells is central to the pathology of PH in animal models and in humans. Methionine aminopeptidase-2 (MetAP2) regulat...

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Autores principales: Kass, Daniel J., Rattigan, Eileen, Kahloon, Rehan, Loh, Katrina, Yu, Liyang, Savir, Asaf, Markowski, Mark, Saqi, Anjali, Rajkumar, Revathi, Ahmad, Ferhaan, Champion, Hunter C.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3324555/
https://ncbi.nlm.nih.gov/pubmed/22509410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035388
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