Early Treatment with Fumagillin, an Inhibitor of Methionine Aminopeptidase-2, Prevents Pulmonary Hypertension in Monocrotaline-Injured Rats

Pulmonary Hypertension (PH) is a pathophysiologic condition characterized by hypoxemia and right ventricular strain. Proliferation of fibroblasts, smooth muscle cells, and endothelial cells is central to the pathology of PH in animal models and in humans. Methionine aminopeptidase-2 (MetAP2) regulat...

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Detalhes bibliográficos
Main Authors: Kass, Daniel J., Rattigan, Eileen, Kahloon, Rehan, Loh, Katrina, Yu, Liyang, Savir, Asaf, Markowski, Mark, Saqi, Anjali, Rajkumar, Revathi, Ahmad, Ferhaan, Champion, Hunter C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3324555/
https://ncbi.nlm.nih.gov/pubmed/22509410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035388
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