Lopinavir/ritonavir significantly influences pharmacokinetic exposure of artemether/lumefantrine in HIV-infected Ugandan adults

BACKGROUND: Treatment of HIV/malaria-coinfected patients with antiretroviral therapy (ART) and artemisinin-based combination therapy has potential for drug interactions. We investigated the pharmacokinetics of artemether, dihydroartemisinin and lumefantrine after administration of a single dose of 8...

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Hlavní autoři: Byakika-Kibwika, Pauline, Lamorde, Mohammed, Okaba-Kayom, Violet, Mayanja-Kizza, Harriet, Katabira, Elly, Hanpithakpong, Warunee, Pakker, Nadine, Dorlo, Thomas P. C., Tarning, Joel, Lindegardh, Niklas, de Vries, Peter J., Back, David, Khoo, Saye, Merry, Concepta
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2012
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3324422/
https://ncbi.nlm.nih.gov/pubmed/22316571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkr596
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