Tumor-Targeted Delivery of IL-2 by NKG2D Leads to Accumulation of Antigen-Specific CD8+ T Cells in the Tumor Loci and Enhanced Anti-Tumor Effects

Interleukin-2 (IL-2) has been shown to promote tumor-specific T-cell proliferation and differentiation but systemic administration of IL-2 results in significant toxicity. Therefore, a strategy that can specifically deliver IL-2 to the tumor location may alleviate concerns of toxicity. Because NKG2D...

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Detalhes bibliográficos
Main Authors: Kang, Tae Heung, Mao, Chih-Ping, He, Liangmei, Tsai, Ya-Chea, Liu, Katherine, La, Victor, Wu, T.-C., Hung, Chien-Fu
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3324421/
https://ncbi.nlm.nih.gov/pubmed/22509395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035141
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