The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and survival of Ly6C(−) monocytes

Transcription factors that regulate monocyte subset differentiation in bone marrow have not yet been identified. Here we show that the orphan nuclear receptor NR4A1 controls Ly6C(−) monocyte differentiation. Ly6C(−) monocytes , which function in a surveillance role in circulation, were absent in Nr4...

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Bibliografiske detaljer
Main Authors: Hanna, Richard N., Carlin, Leo M., Hubbeling, Harper G., Nackiewicz, Dominika, Green, Angela M., Punt, Jennifer A., Geissmann, Frederic, Hedrick, Catherine C.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3324395/
https://ncbi.nlm.nih.gov/pubmed/21725321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2063
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