Deleting an Nr4a1 super-enhancer subdomain ablates Ly6C(low) monocytes while preserving macrophage gene function

Mononuclear phagocytes are a heterogeneous family that occupy all tissues and assume numerous roles to support tissue function and systemic homeostasis. Our ability to dissect the roles of individual subsets is limited by a lack of technologies that ablate gene function within specific mononuclear p...

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Veröffentlicht in:Immunity
Hauptverfasser: Thomas, Graham D., Hanna, Richard N., Vasudevan, Neelakatan T., Hamers, Anouk A., Romanoski, Casey E., McArdale, Sara, Ross, Kevin, Blatchley, Amy, Yoakum, Debbi, Hamilton, Bruce A., Mikulski, Zbigniew, Jain, Mukesh K., Glass, Christopher K., Hedrick, Catherine C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5694686/
https://ncbi.nlm.nih.gov/pubmed/27814941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2016.10.011
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