Deleting an Nr4a1 super-enhancer subdomain ablates Ly6C(low) monocytes while preserving macrophage gene function

Mononuclear phagocytes are a heterogeneous family that occupy all tissues and assume numerous roles to support tissue function and systemic homeostasis. Our ability to dissect the roles of individual subsets is limited by a lack of technologies that ablate gene function within specific mononuclear p...

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Publicat a:Immunity
Autors principals: Thomas, Graham D., Hanna, Richard N., Vasudevan, Neelakatan T., Hamers, Anouk A., Romanoski, Casey E., McArdale, Sara, Ross, Kevin, Blatchley, Amy, Yoakum, Debbi, Hamilton, Bruce A., Mikulski, Zbigniew, Jain, Mukesh K., Glass, Christopher K., Hedrick, Catherine C.
Format: Artigo
Idioma:Inglês
Publicat: 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5694686/
https://ncbi.nlm.nih.gov/pubmed/27814941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2016.10.011
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