BASE EXCISION REPAIR AND DESIGN OF SMALL MOLECULE INHIBITORS OF HUMAN DNA POLYMERASE β

Base excision repair (BER) can protect a cell after endogenous or exogenous genotoxic stress, and a deficiency in BER can render a cell hypersensitive to stress-induced apoptotic and necrotic cell death, mutagenesis, and chromosomal rearrangements. However, understanding of the mammalian BER system...

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Autors principals: Wilson, Samuel H., Beard, William A., Shock, David D., Batra, Vinod K., Cavanaugh, Nisha A., Prasad, Rajendra, Hou, Esther W., Liu, Yuan, Asagoshi, Kenjiro, Horton, Julie K., Stefanick, Donna F., Kedar, Padmini S., Carrozza, Michael J., Masaoka, Aya, Heacock, Michelle L.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3324036/
https://ncbi.nlm.nih.gov/pubmed/20844920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-010-0489-1
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