Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor–mediated upregulation of caveolin-1

Caveolin-1 (CAV1) is an essential structural constituent of caveolae, specialized lipid raft microdomains on the cell membrane involved in endocytosis and signal transduction, which are inexplicably deregulated and are associated with aggressiveness in numerous cancers. Here we identify CAV1 as a di...

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Bibliografiska uppgifter
Huvudupphovsmän: Wang, Yi, Roche, Olga, Xu, Chaoying, Moriyama, Eduardo H., Heir, Pardeep, Chung, Jacky, Roos, Frederik C., Chen, Yonghong, Finak, Greg, Milosevic, Michael, Wilson, Brian C., Teh, Bin Tean, Park, Morag, Irwin, Meredith S., Ohh, Michael
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2012
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323978/
https://ncbi.nlm.nih.gov/pubmed/22411794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1112129109
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