Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor–mediated upregulation of caveolin-1

Caveolin-1 (CAV1) is an essential structural constituent of caveolae, specialized lipid raft microdomains on the cell membrane involved in endocytosis and signal transduction, which are inexplicably deregulated and are associated with aggressiveness in numerous cancers. Here we identify CAV1 as a di...

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Detalhes bibliográficos
Main Authors: Wang, Yi, Roche, Olga, Xu, Chaoying, Moriyama, Eduardo H., Heir, Pardeep, Chung, Jacky, Roos, Frederik C., Chen, Yonghong, Finak, Greg, Milosevic, Michael, Wilson, Brian C., Teh, Bin Tean, Park, Morag, Irwin, Meredith S., Ohh, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323978/
https://ncbi.nlm.nih.gov/pubmed/22411794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1112129109
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