Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor–mediated upregulation of caveolin-1

Caveolin-1 (CAV1) is an essential structural constituent of caveolae, specialized lipid raft microdomains on the cell membrane involved in endocytosis and signal transduction, which are inexplicably deregulated and are associated with aggressiveness in numerous cancers. Here we identify CAV1 as a di...

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Detaylı Bibliyografya
Asıl Yazarlar: Wang, Yi, Roche, Olga, Xu, Chaoying, Moriyama, Eduardo H., Heir, Pardeep, Chung, Jacky, Roos, Frederik C., Chen, Yonghong, Finak, Greg, Milosevic, Michael, Wilson, Brian C., Teh, Bin Tean, Park, Morag, Irwin, Meredith S., Ohh, Michael
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2012
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323978/
https://ncbi.nlm.nih.gov/pubmed/22411794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1112129109
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