Signal transducer and activator of transcription-3/suppressor of cytokine signaling-3 (STAT3/SOCS3) axis in myeloid cells regulates neuroinflammation

Suppressor of cytokine signaling (SOCS) proteins are feedback inhibitors of the JAK/STAT pathway. SOCS3 has a crucial role in inhibiting STAT3 activation, cytokine signaling, and inflammatory gene expression in macrophages/microglia. To determine the role of SOCS3 in myeloid cells in neuroinflammati...

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Bibliografiske detaljer
Main Authors: Qin, Hongwei, Yeh, Wen-I, De Sarno, Patrizia, Holdbrooks, Andrew T., Liu, Yudong, Muldowney, Michelle T., Reynolds, Stephanie L., Yanagisawa, Lora L., Fox, Thomas H., Park, Keun, Harrington, Laurie E., Raman, Chander, Benveniste, Etty N.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323949/
https://ncbi.nlm.nih.gov/pubmed/22411837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1117218109
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