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Improvement of PCR reaction conditions for site-directed mutagenesis of big plasmids

QuickChange mutagenesis is the method of choice for site-directed mutagenesis (SDM) of target sequences in a plasmid. It can be applied successfully to small plasmids (up to 10 kb). However, this method cannot efficiently mutate bigger plasmids. Using KOD Hot Start polymerase in combination with hig...

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Bibliografische gegevens
Hoofdauteurs: Munteanu, Bogdan, Braun, Mario, Boonrod, Kajohn
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Zhejiang University Press 2012
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323938/
https://ncbi.nlm.nih.gov/pubmed/22467364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1631/jzus.B1100180
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