Rapamycin Inhibits Lymphatic Endothelial Cell Tube Formation by Downregulating Vascular Endothelial Growth Factor Receptor 3 Protein Expression

Mammalian target of rapamycin (mTOR) controls lymphangiogenesis. However, the underlying mechanism is not clear. Here we show that rapamycin suppressed insulin-like growth factor 1 (IGF-1)- or fetal bovine serum (FBS)-stimulated lymphatic endothelial cell (LEC) tube formation, an in vitro model of l...

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Main Authors: Luo, Yan, Liu, Lei, Rogers, Donna, Su, Wei, Odaka, Yoshinobu, Zhou, Hongyu, Chen, Wenxing, Shen, Tao, Alexander, J Steven, Huang, Shile
Formato: Artigo
Idioma:Inglês
Publicado: Neoplasia Press Inc. 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323900/
https://ncbi.nlm.nih.gov/pubmed/22496622
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