The fungicide ciclopirox inhibits lymphatic endothelial cell tube formation by suppressing VEGFR-3-mediated ERK signaling pathway

Ciclopirox olamine (CPX), an off-patent antifungal agent used to treat mycoses of skin and nails, has recently been demonstrated to be a potential anticancer agent. However, the underlying mechanism is not well understood. Here for the first time we show that CPX inhibited lymphangiogenesis in an in...

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Main Authors: Luo, Yan, Zhou, Hongyu, Liu, Lei, Shen, Tao, Chen, Wenxing, Xu, Baoshan, Han, Xiuzhen, Zhang, Fangfang, Scott, Rona S., Alexander, J. Steven, Alam, Antoine, Huang, Shile
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3088775/
https://ncbi.nlm.nih.gov/pubmed/21217783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.590
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