Quantitative functions of Argonaute proteins in mammalian development

Argonaute proteins (Ago1–4) are essential components of the microRNA-induced silencing complex and play important roles in both microRNA biogenesis and function. Although Ago2 is the only one with the slicer activity, it is not clear whether the slicer activity is a universally critical determinant...

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Autors principals: Wang, Dongmei, Zhang, Zhaojie, O'Loughlin, Evan, Lee, Thomas, Houel, Stephane, O'Carroll, Dónal, Tarakhovsky, Alexander, Ahn, Natalie G., Yi, Rui
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2012
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323880/
https://ncbi.nlm.nih.gov/pubmed/22474261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.182758.111
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