The specific role of pRb in p16(INK4A)-mediated arrest of normal and malignant human breast cells

RB family proteins pRb, p107 and p130 have similar structures and overlapping functions, enabling cell cycle arrest and cellular senescence. pRb, but not p107 or p130, is frequently mutated in human malignancies. In human fibroblasts acutely exposed to oncogenic ras, pRb has a specific role in suppr...

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Bibliografiske detaljer
Main Authors: Bazarov, Alexey V, Lee, Won Jae, Bazarov, Irina, Bosire, Moses, Hines, William C, Stankovich, Basha, Chicas, Agustin, Lowe, Scott W, Yaswen, Paul
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2012
Fag:
Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323799/
https://ncbi.nlm.nih.gov/pubmed/22333593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.11.5.19492
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