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Activation of Cell Cycle Arrest and Apoptosis by the Proto-Oncogene Pim-2

Potent survival effects have been ascribed to the serine/threonine kinase proto-oncogene PIM-2. Elevated levels of PIM-2 are associated with various malignancies. In human cells, a single Pim-2 transcript gives rise mainly to two protein isoforms (34, 41 kDa) that share an identical catalytic site b...

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Autors principals: Levy, Daphna, Davidovich, Ateret, Zirkin, Shahar, Frug, Yulia, Cohen, Amos M., Shalom, Sara, Don, Jeremy
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323563/
https://ncbi.nlm.nih.gov/pubmed/22506047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034736
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