Lack of neuroprotection of inhibitory peptides targeting Jun/JNK after transient focal cerebral ischemia in Spontaneously Hypertensive rats

In this study, we have assessed the ability of two TAT-fused peptides PYC36-TAT and JNKI-1-TAT (JNKI-1 or XG-102), which respectively inhibit jun proto-oncogene (c-Jun) and c-Jun N-terminal kinase (JNK) activation, to reduce infarct volume and improve functional outcome (adhesive tape removal) after...

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Bibliografiske detaljer
Main Authors: Gow, William R, Campbell, Kym, Meade, Amanda J, Watt, Paul M, Milech, Nadia, Knuckey, Neville W, Meloni, Bruno P
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2011
Fag:
Negative Result
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3323192/
https://ncbi.nlm.nih.gov/pubmed/21971350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2011.140
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