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Up-regulation of Pro-apoptotic Protein Bim and Down-regulation of Anti-apoptotic Protein Mcl-1 Cooperatively Mediate Enhanced Tumor Cell Death Induced by the Combination of ERK Kinase (MEK) Inhibitor and Microtubule Inhibitor

Blockade of the ERK signaling pathway by ERK kinase (MEK) inhibitors selectively enhances the induction of apoptosis by microtubule inhibitors in tumor cells in which this pathway is constitutively activated. We examined the mechanism by which such drug combinations induce enhanced cell death by app...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Kawabata, Takumi, Tanimura, Susumu, Asai, Kohei, Kawasaki, Ryohei, Matsumaru, Yumi, Kohno, Michiaki
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2012
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322996/
https://ncbi.nlm.nih.gov/pubmed/22270368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.319426
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