Cytochrome b Mutation Y268S Conferring Atovaquone Resistance Phenotype in Malaria Parasite Results in Reduced Parasite bc(1) Catalytic Turnover and Protein Expression

Atovaquone is an anti-malarial drug used in combination with proguanil (e.g. Malarone(TM)) for the curative and prophylactic treatment of malaria. Atovaquone, a 2-hydroxynaphthoquinone, is a competitive inhibitor of the quinol oxidation (Q(o)) site of the mitochondrial cytochrome bc(1) complex. Inhi...

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Bibliografiske detaljer
Main Authors: Fisher, Nicholas, Abd Majid, Roslaini, Antoine, Thomas, Al-Helal, Mohammed, Warman, Ashley J., Johnson, David J., Lawrenson, Alexandre S., Ranson, Hilary, O'Neill, Paul M., Ward, Stephen A., Biagini, Giancarlo A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Enzymology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322985/
https://ncbi.nlm.nih.gov/pubmed/22282497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.324319
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