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Lack of Evidence for Presenilins as Endoplasmic Reticulum Ca(2+) Leak Channels
Familial Alzheimer disease (FAD) is linked to mutations in the presenilin (PS) homologs. FAD mutant PS expression has several cellular consequences, including exaggerated intracellular Ca(2+) ([Ca(2+)](i)) signaling due to enhanced agonist sensitivity and increased magnitude of [Ca(2+)](i) signals....
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3322867/ https://ncbi.nlm.nih.gov/pubmed/22311977 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.300491 |
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