Ubiquitin-specific Protease 4 Mitigates Toll-like/Interleukin-1 Receptor Signaling and Regulates Innate Immune Activation

The Toll-like receptor (TLR)/IL-1 receptor (IL-1R) signaling pathway is essential for innate immune responses and immune homeostasis. Lys-63-polyubiquitinated TRAF6 mediates its downstream signaling activation. In a gain-of-expression screen of 66 different deubiquitinating enzymes, we identified US...

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Detalhes bibliográficos
Main Authors: Zhou, FangFang, Zhang, Xiaofei, van Dam, Hans, ten Dijke, Peter, Huang, Huizhe, Zhang, Long
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322833/
https://ncbi.nlm.nih.gov/pubmed/22262844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.328187
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