Variation in genome-wide mutation rates within and between human families

J.B.S. Haldane proposed in 1947 that the male germline may be more mutagenic than the female (1). Diverse studies have supported Haldane’s contention of a higher average mutation rate in the male germline in a variety of mammals, including humans (e.g. (2,3)). Here we present the first direct compar...

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Detalhes bibliográficos
Main Authors: Conrad, Donald F., Keebler, Jonathan E.M., DePristo, Mark A., Lindsay, Sarah J., Zhang, Yujun, Cassals, Ferran, Idaghdour, Youssef, Hartl, Chris L., Torroja, Carlos, Garimella, Kiran V., Zilversmit, Martine, Cartwright, Reed, Rouleau, Guy, Daly, Mark, Stone, Eric A., Hurles, Matthew E., Awadalla, Philip
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322360/
https://ncbi.nlm.nih.gov/pubmed/21666693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.862
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