Variation in genome-wide mutation rates within and between human families

J.B.S. Haldane proposed in 1947 that the male germline may be more mutagenic than the female (1). Diverse studies have supported Haldane’s contention of a higher average mutation rate in the male germline in a variety of mammals, including humans (e.g. (2,3)). Here we present the first direct compar...

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Main Authors: Conrad, Donald F., Keebler, Jonathan E.M., DePristo, Mark A., Lindsay, Sarah J., Zhang, Yujun, Cassals, Ferran, Idaghdour, Youssef, Hartl, Chris L., Torroja, Carlos, Garimella, Kiran V., Zilversmit, Martine, Cartwright, Reed, Rouleau, Guy, Daly, Mark, Stone, Eric A., Hurles, Matthew E., Awadalla, Philip
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322360/
https://ncbi.nlm.nih.gov/pubmed/21666693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.862
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