Ternary interactions of spermine with DNA: 4'-epiadriamycin and other DNA: anthracycline complexes.

The recently developed anthracycline 4'-epiadriamycin, an anti-cancer drug with improved activity, differs from adriamycin by inversion of the stereochemistry at the 4'-position. We have cocrystallized 4'-epiadriamycin with the DNA hexamer d(CGATCG) and solved the structure to 1.5 A r...

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Bibliographic Details
Main Authors: Williams, L D, Frederick, C A, Ughetto, G, Rich, A
Format: Artigo
Language:Inglês
Published: 1990
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC332234/
https://ncbi.nlm.nih.gov/pubmed/2216725
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