PRC1 and PRC2 Are Not Required for Targeting of H2A.Z to Developmental Genes in Embryonic Stem Cells

The essential histone variant H2A.Z localises to both active and silent chromatin sites. In embryonic stem cells (ESCs), H2A.Z is also reported to co-localise with polycomb repressive complex 2 (PRC2) at developmentally silenced genes. The mechanism of H2A.Z targeting is not clear, but a role for th...

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Hauptverfasser: Illingworth, Robert S., Botting, Catherine H., Grimes, Graeme R., Bickmore, Wendy A., Eskeland, Ragnhild
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3322156/
https://ncbi.nlm.nih.gov/pubmed/22496869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0034848
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