Delineation of antigen-specific and antigen-nonspecific CD8(+) memory T-cell responses after cytokine-based cancer immunotherapy

Memory T cells exhibit tremendous antigen specificity within the immune system and accumulate with age. Our studies reveal an antigen-independent expansion of memory, but not naive, CD8(+) T cells after several immunotherapeutic regimens for cancer resulting in a distinctive phenotype. Signaling thr...

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Detalhes bibliográficos
Main Authors: Tietze, Julia K., Wilkins, Danice E. C., Sckisel, Gail D., Bouchlaka, Myriam N., Alderson, Kory L., Weiss, Jonathan M., Ames, Erik, Bruhn, Kevin W., Craft, Noah, Wiltrout, Robert H., Longo, Dan L., Lanier, Lewis L., Blazar, Bruce R., Redelman, Doug, Murphy, William J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321869/
https://ncbi.nlm.nih.gov/pubmed/22251483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-07-369736
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