Preclinical Corrective Gene Transfer in Xeroderma Pigmentosum Human Skin Stem Cells

Xeroderma pigmentosum (XP) is a devastating disease associated with dramatic skin cancer proneness. XP cells are deficient in nucleotide excision repair (NER) of bulky DNA adducts including ultraviolet (UV)-induced mutagenic lesions. Approaches of corrective gene transfer in NER-deficient keratinocy...

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Autors principals: Warrick, Emilie, Garcia, Marta, Chagnoleau, Corinne, Chevallier, Odile, Bergoglio, Valérie, Sartori, Daniela, Mavilio, Fulvio, Angulo, Jaime F, Avril, Marie-Françoise, Sarasin, Alain, Larcher, Fernando, Del Rio, Marcela, Bernerd, Françoise, Magnaldo, Thierry
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2012
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321585/
https://ncbi.nlm.nih.gov/pubmed/22068429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.233
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