The Microtubule-Stabilizing Agent, Epothilone D, Reduces Axonal Dysfunction, Neurotoxicity, Cognitive Deficits, and Alzheimer-Like Pathology in an Interventional Study with Aged Tau Transgenic Mice

Neurodegenerative tauopathies, such as Alzheimer's disease (AD), are characterized by insoluble deposits of hyperphosphorylated tau protein within brain neurons. Increased phosphorylation and decreased solubility has been proposed to diminish normal tau stabilization of microtubules (MTs), ther...

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Main Authors: Zhang, Bin, Carroll, Jenna, Trojanowski, John Q., Yao, Yuemang, Iba, Michiyo, Potuzak, Justin S., Hogan, Anne-Marie L., Xie, Sharon X., Ballatore, Carlo, Smith, Amos B., Lee, Virginia M.-Y., Brunden, Kurt R.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2012
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321513/
https://ncbi.nlm.nih.gov/pubmed/22423084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4922-11.2012
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