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Mechanisms Underlying Tolerance after Long-Term Benzodiazepine Use: A Future for Subtype-Selective GABA(A) Receptor Modulators?

Despite decades of basic and clinical research, our understanding of how benzodiazepines tend to lose their efficacy over time (tolerance) is at least incomplete. In appears that tolerance develops relatively quickly for the sedative and anticonvulsant actions of benzodiazepines, whereas tolerance t...

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Bibliografski detalji
Glavni autori: Vinkers, Christiaan H., Olivier, Berend
Format: Artigo
Jezik:Inglês
Izdano: Hindawi Publishing Corporation 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3321276/
https://ncbi.nlm.nih.gov/pubmed/22536226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/416864
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