Effect of Carcinogenic Acrolein on DNA Repair and Mutagenic Susceptibility

Acrolein (Acr), a ubiquitous environmental contaminant, is a human carcinogen. Acr can react with DNA to form mutagenic α- and γ-hydroxy-1, N(2)-cyclic propano-2′-deoxyguanosine adducts (α-OH-Acr-dG and γ-OH-Acr-dG). We demonstrate here that Acr-dG adducts can be efficiently repaired by the nucleoti...

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Bibliografiske detaljer
Main Authors: Wang, Hsiang-Tsui, Hu, Yu, Tong, Dan, Huang, Jian, Gu, Liya, Wu, Xue-Ru, Chung, Fung-Lung, Li, Guo-Min, Tang, Moon-shong
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
DNA and Chromosomes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3320987/
https://ncbi.nlm.nih.gov/pubmed/22275365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.329623
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