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Daunomycin modifies the sequence-selective recognition of DNA by actinomycin.

The antitumour antibiotic actinomycin D normally binds to DNA by intercalation at sequences containing the CpG step, but in the presence of daunomycin it has been reported to interact with poly(dA-dT). This observation has neither been confirmed nor explained. Here we have used a photoreactive 7-azi...

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Main Authors: Ridge, G S, Bailly, C, Graves, D E, Waring, M J
格式: Artigo
語言:Inglês
出版: 1994
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC332067/
https://ncbi.nlm.nih.gov/pubmed/7816612
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