Modification of Ad5 Hexon Hypervariable Regions Circumvents Pre-Existing Ad5 Neutralizing Antibodies and Induces Protective Immune Responses

The development of an effective malaria vaccine is a high global health priority. Vaccine vectors based on adenovirus type 5 are capable of generating robust and protective T cell and antibody responses in animal models and are currently being evaluated in clinical trials for HIV and malaria. They a...

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Detalhes bibliográficos
Main Authors: Bruder, Joseph T., Semenova, Elena, Chen, Ping, Limbach, Keith, Patterson, Noelle B., Stefaniak, Maureen E., Konovalova, Svetlana, Thomas, Charlie, Hamilton, Melissa, King, C. Richter, Richie, Thomas L., Doolan, Denise L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3320611/
https://ncbi.nlm.nih.gov/pubmed/22496772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0033920
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