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A Paradigm for Enzyme-Catalyzed Proton Transfer at Carbon: Triosephosphate Isomerase

Triosephosphate isomerase (TIM) catalyzes the stereospecific 1,2-proton shift at dihydroxyacetone phosphate (DHAP) to give (R)-glyceraldehyde 3-phosphate through a pair of isomeric enzyme-bound cis-enediolate phosphate intermediates. The chemical transformations that occur at the active site of TIM...

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Bibliografske podrobnosti
Glavni avtor: Richard, John P.
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3319633/
https://ncbi.nlm.nih.gov/pubmed/22409228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi300195b
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