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Enzyme Architecture: Remarkably Similar Transition States for Triosephosphate Isomerase-Catalyzed Reactions of the Whole Substrate and the Substrate in Pieces

[Image: see text] Values of (k(cat)/K(m))(GAP) for triosephosphate isomerase-catalyzed reactions of (R)-glyceraldehyde 3-phosphate and k(cat)/K(HP(i))K(GA) for reactions of the substrate pieces glycolaldehyde and HPO(3)(2–) have been determined for wild-type and the following TIM mutants: I172V, I17...

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Detalhes bibliográficos
Main Authors: Zhai, Xiang, Amyes, Tina L., Richard, John P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985921/
https://ncbi.nlm.nih.gov/pubmed/24588650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja501103b
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