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Solid-Phase Synthesis of Tailed Cyclic RGD Peptides Using Glutamic Acid: Unexpected Glutarimide Formation

To provide multiple conjugating sites on cyclic peptides for their increasing biomedical applications, a tailed cyclic RGD peptide, c[RGDfE(GGGKK-NH(2))] was designed with c(RGDfE) linked through Glu to a tail consisting of a spacer of three Gly residues and a linker of two Lys residues. The spacer...

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Detalhes bibliográficos
Main Authors: Zhu, Junmin, Marchant, Roger E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3319412/
https://ncbi.nlm.nih.gov/pubmed/18085515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psc.975
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