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EX VIVO SPINAL CORD SLICE MODEL OF NEUROMYELITIS OPTICA REVEALS NOVEL IMMUNOPATHOGENIC MECHANISMS

OBJECTIVE: Neuromyelitis optica (NMO) is a neuroinflammatory disease of spinal cord and optic nerve associated with serum autoantibodies (NMO-IgG) against astrocyte water channel aquaporin-4 (AQP4). Recent studies suggest that AQP4 autoantibodies are pathogenic. The objectives of this study were to...

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Bibliografske podrobnosti
Main Authors: Zhang, Hua, Bennett, Jeffrey L., Verkman, A. S.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3319401/
https://ncbi.nlm.nih.gov/pubmed/22069219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.22551
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