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Charge Distribution and Imperfect Amphipathicity Affect Pore Formation by Antimicrobial Peptides

Antimicrobial peptides often permeabilize biological membranes via a pore mechanism. Two pore types have been proposed: toroidal, where the pore is partly lined by lipid, and barrel-stave, where a cylindrical pore is completely lined by peptides. What drives the preference of antimicrobial peptides...

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Autors principals: Mihajlovic, Maja, Lazaridis, Themis
Format: Artigo
Idioma:Inglês
Publicat: 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3319260/
https://ncbi.nlm.nih.gov/pubmed/22290189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamem.2012.01.016
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