Systemic elevation of PTEN induces a tumor suppressive metabolic state

Decremental loss of PTEN results in cancer susceptibility and tumor progression. In turn this raises the possibility that PTEN elevation might be an attractive option for cancer prevention and therapy. We have generated several transgenic mouse lines with variably elevated PTEN expression levels, ta...

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Detalhes bibliográficos
Main Authors: Garcia-Cao, Isabel, Song, Min Sup, Hobbs, Robin M., Laurent, Gaelle, Giorgi, Carlotta, de Boer, Vincent C.J., Anastasiou, Dimitrios, Ito, Keisuke, Sasaki, Atsuo T., Rameh, Lucia, Carracedo, Arkaitz, Vander Heiden, Matthew G., Cantley, Lewis C., Pinton, Paolo, Haigis, Marcia C., Pandolfi, Pier Paolo
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3319228/
https://ncbi.nlm.nih.gov/pubmed/22401813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.02.030
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